Trabecular bone-formation rate in tibiae of control (+/+)
and osteonectin-null (–/–) mice. In vivo dual calcein
labeling allows an estimate of bone-formation rate, which considers the distance
between 2 fluorescent labels. Representative data from 11-week-old control
(a) and osteonectin-null (b) mice are shown. Bars
show mean ± SEM (n ≥ 4).
AP <0.01 between control and mutant
mice, as determined by 2-way ANOVA.