Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Erratum Free access | 10.1172/JCI70180

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

Min Luo, Xiaoqun Guan, Elizabeth D. Luczak, Di Lang, William Kutschke, Zhan Gao, Jinying Yang, Patric Glynn, Samuel Sossalla, Paari D. Swaminathan, Robert M. Weiss, Baoli Yang, Adam G. Rokita, Lars S. Maier, Igor R. Efimov, Thomas J. Hund, and Mark E. Anderson

Find articles by Luo, M. in: PubMed | Google Scholar

Find articles by Guan, X. in: PubMed | Google Scholar

Find articles by Luczak, E. in: PubMed | Google Scholar

Find articles by Lang, D. in: PubMed | Google Scholar

Find articles by Kutschke, W. in: PubMed | Google Scholar

Find articles by Gao, Z. in: PubMed | Google Scholar

Find articles by Yang, J. in: PubMed | Google Scholar

Find articles by Glynn, P. in: PubMed | Google Scholar

Find articles by Sossalla, S. in: PubMed | Google Scholar

Find articles by Swaminathan, P. in: PubMed | Google Scholar

Find articles by Weiss, R. in: PubMed | Google Scholar

Find articles by Yang, B. in: PubMed | Google Scholar

Find articles by Rokita, A. in: PubMed | Google Scholar

Find articles by Maier, L. in: PubMed | Google Scholar

Find articles by Efimov, I. in: PubMed | Google Scholar

Find articles by Hund, T. in: PubMed | Google Scholar

Find articles by Anderson, M. in: PubMed | Google Scholar

Published May 1, 2013 - More info

Published in Volume 123, Issue 5 on May 1, 2013
J Clin Invest. 2013;123(5):2333–2333. https://doi.org/10.1172/JCI70180.
© 2013 The American Society for Clinical Investigation
Published May 1, 2013 - Version history
View PDF

Related article:

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII
Min Luo, … , Thomas J. Hund, Mark E. Anderson
Min Luo, … , Thomas J. Hund, Mark E. Anderson
Research Article Cardiology

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

  • Text
  • PDF
Abstract

Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction, but the mechanisms underlying increased mortality are unknown. Mice with streptozotocin-induced diabetes developed profound heart rate slowing and doubled mortality compared with controls after myocardial infarction. Oxidized Ca2+/calmodulin-dependent protein kinase II (ox-CaMKII) was significantly increased in pacemaker tissues from diabetic patients compared with that in nondiabetic patients after myocardial infarction. Streptozotocin-treated mice had increased pacemaker cell ox-CaMKII and apoptosis, which were further enhanced by myocardial infarction. We developed a knockin mouse model of oxidation-resistant CaMKIIδ (MM-VV), the isoform associated with cardiovascular disease. Streptozotocin-treated MM-VV mice and WT mice infused with MitoTEMPO, a mitochondrial targeted antioxidant, expressed significantly less ox-CaMKII, exhibited increased pacemaker cell survival, maintained normal heart rates, and were resistant to diabetes-attributable mortality after myocardial infarction. Our findings suggest that activation of a mitochondrial/ox-CaMKII pathway contributes to increased sudden death in diabetic patients after myocardial infarction.

Authors

Min Luo, Xiaoqun Guan, Elizabeth D. Luczak, Di Lang, William Kutschke, Zhan Gao, Jinying Yang, Patric Glynn, Samuel Sossalla, Paari D. Swaminathan, Robert M. Weiss, Baoli Yang, Adam G. Rokita, Lars S. Maier, Igor R. Efimov, Thomas J. Hund, Mark E. Anderson

×

Original citation: J. Clin. Invest. 2013;123(3):1262–1274. doi:10.1172/JCI65268.

Citation for this erratum: J. Clin. Invest. 2013;123(5):2333. doi:10.1172/JCI70180.

During the preparation of this manuscript, Figure 6, A and B, was inadvertently mislabeled. The correct figure is below.

Figure 6

The JCI regrets the error.

Version history
  • Version 1 (May 1, 2013): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts