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Usage Information

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
Janet L. Crane, Xu Cao
Janet L. Crane, Xu Cao
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Science in Medicine

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

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Abstract

During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.

Authors

Janet L. Crane, Xu Cao

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 2,611 389
PDF 425 66
Figure 448 2
Citation downloads 307 0
Totals 3,791 457
Total Views 4,248
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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