Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • Hypoxia-inducible factors in disease pathophysiology and therapeutics (Oct 2020)
    • Latency in Infectious Disease (Jul 2020)
    • Immunotherapy in Hematological Cancers (Apr 2020)
    • Big Data's Future in Medicine (Feb 2020)
    • Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
    • Reparative Immunology (Jul 2019)
    • View all review series ...
  • Viewpoint
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
Predicting response to epigenetic therapy
Marianne B. Treppendahl, … , Lasse S. Kristensen, Kirsten Grønbæk
Marianne B. Treppendahl, … , Lasse S. Kristensen, Kirsten Grønbæk
Published January 2, 2014
Citation Information: J Clin Invest. 2014;124(1):47-55. https://doi.org/10.1172/JCI69737.
View: Text | PDF
Review Series

Predicting response to epigenetic therapy

  • Text
  • PDF
Abstract

Drugs targeting the epigenome are new promising cancer treatment modalities; however, not all patients receive the same benefit from these drugs. In contrast to conventional chemotherapy, responses may take several months after the initiation of treatment to occur. Accordingly, identification of good pretreatment predictors of response is of great value. Many clinical parameters and molecular targets have been tested in preclinical and clinical studies with varying results, leaving room for optimization. Here we provide an overview of markers that may predict the efficacy of FDA- and EMA-approved epigenetic drugs.

Authors

Marianne B. Treppendahl, Lasse S. Kristensen, Kirsten Grønbæk

×

Figure 1

Mechanism of action DNMTis.

Options: View larger image (or click on image) Download as PowerPoint
Mechanism of action DNMTis.
(A) Under normal circumstances, the DNMTs co...
(A) Under normal circumstances, the DNMTs copy the methylation pattern of the parental DNA strand after replication, ensuring that methylation patterns are maintained during cell division. (B) During treatment, DNMTis are incorporated into DNA and RNA, where they covalently bind and thus inactivate DNMTs. After successive cell divisions, the original DNA methylation pattern is lost.
Follow JCI:
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts