As I draft this editorial, it is almost a year into our stewardship as editors of the JCI. Previous Journal Editors have told me that the evaluation of manuscripts submitted across a broad range of topics and specialties was a highlight for their time as JCI Editor. I’ve found this to be no less true in my case, and I can speak confidently that the entire Editorial Board feels the same enjoyment. As I reflect upon the past year, I’m struck by feelings that range from immense privilege, to enormous responsibility, to, at times, near apoplectic bewilderment.
