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Usage Information

Multiple functions of a glioblastoma fusion oncogene
Ivan Babic, Paul S. Mischel
Ivan Babic, Paul S. Mischel
Published January 9, 2013
Citation Information: J Clin Invest. 2013;123(2):548-551. https://doi.org/10.1172/JCI67658.
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Commentary

Multiple functions of a glioblastoma fusion oncogene

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Abstract

RNA sequencing facilitates the discovery of novel gene fusions in cancer. In this issue of the JCI, Parker et al. identify an FGFR3-TACC3 fusion oncogene in glioblastoma and demonstrate a novel mechanism of pathogenicity. A miR-99a binding site within the 3′–untranslated region (3′-UTR) of FGFR3 is lost, releasing FGFR3 signaling from miR-99a–dependent inhibition and greatly enhancing tumor progression relative to WT FGFR3. These results provide compelling insight into the pathogenicity of a novel fusion oncogene and suggest new therapeutic approaches for a subset of glioblastomas.

Authors

Ivan Babic, Paul S. Mischel

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Usage data is cumulative from July 2024 through July 2025.

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Figure 62 0
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