Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Aging (Upcoming)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Clarification Free access | 10.1172/JCI66865

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

Laurel Yong-Hwa Lee, Do Lien Anh Ha, Cameron Simmons, Menno D. de Jong, Nguyen Van Vinh Chau, Reto Schumacher, Yan Chun Peng, Andrew J. McMichael, Jeremy J. Farrar, Geoffrey L. Smith, Alain R.M. Townsend, Brigitte A. Askonas, Sarah Rowland-Jones, and Tao Dong

Find articles by Lee, L. in: JCI | PubMed | Google Scholar

Find articles by Ha, D. in: JCI | PubMed | Google Scholar

Find articles by Simmons, C. in: JCI | PubMed | Google Scholar

Find articles by de Jong, M. in: JCI | PubMed | Google Scholar

Find articles by Chau, N. in: JCI | PubMed | Google Scholar

Find articles by Schumacher, R. in: JCI | PubMed | Google Scholar

Find articles by Peng, Y. in: JCI | PubMed | Google Scholar

Find articles by McMichael, A. in: JCI | PubMed | Google Scholar

Find articles by Farrar, J. in: JCI | PubMed | Google Scholar

Find articles by Smith, G. in: JCI | PubMed | Google Scholar

Find articles by Townsend, A. in: JCI | PubMed | Google Scholar

Find articles by Askonas, B. in: JCI | PubMed | Google Scholar

Find articles by Rowland-Jones, S. in: JCI | PubMed | Google Scholar

Find articles by Dong, T. in: JCI | PubMed | Google Scholar

Published November 1, 2012 - More info

Published in Volume 122, Issue 11 on November 1, 2012
J Clin Invest. 2012;122(11):4301–4301. https://doi.org/10.1172/JCI66865.
© 2012 The American Society for Clinical Investigation
Published November 1, 2012 - Version history
View PDF

Related article:

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals
Laurel Yong-Hwa Lee, … , Sarah Rowland-Jones, Tao Dong
Laurel Yong-Hwa Lee, … , Sarah Rowland-Jones, Tao Dong
Research Article

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

  • Text
  • PDF
Abstract

The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are ineffective against strains that have undergone significant antigenic variation. An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. To determine how common cross-reactive T cells are, we performed a comprehensive ex vivo analysis of cross-reactive CD4+ and CD8+ memory T cell responses to overlapping peptides spanning the full proteome of influenza A/Viet Nam/CL26/2005 (H5N1) and influenza A/New York/232/2004 (H3N2) in healthy individuals from the United Kingdom and Viet Nam. Memory CD4+ and CD8+ T cells isolated from the majority of participants exhibited human influenza–specific responses and showed cross-recognition of at least one H5N1 internal protein. Participant CD4+ and CD8+ T cells recognized multiple synthesized influenza peptides, including peptides from the H5N1 strain. Matrix protein 1 (M1) and nucleoprotein (NP) were the immunodominant targets of cross-recognition. In addition, cross-reactive CD4+ and CD8+ T cells recognized target cells infected with recombinant vaccinia viruses expressing either H5N1 M1 or NP. Thus, vaccine formulas inducing heterosubtypic T cell–mediated immunity may confer broad protection against avian and human influenza A viruses.

Authors

Laurel Yong-Hwa Lee, Do Lien Anh Ha, Cameron Simmons, Menno D. de Jong, Nguyen Van Vinh Chau, Reto Schumacher, Yan Chun Peng, Andrew J. McMichael, Jeremy J. Farrar, Geoffrey L. Smith, Alain R.M. Townsend, Brigitte A. Askonas, Sarah Rowland-Jones, Tao Dong

×

Original citation: J. Clin. Invest. 2008;118(10):3478–3490. doi:10.1172/JCI32460.

Citation for this clarification: J. Clin. Invest. 2012;122(11):4301. doi:10.1172/JCI66865.

A concern was raised that the Vietnamese healthy volunteers examined in the study did not provide written consent. Subsequent investigation has revealed that for these healthy volunteers, only oral and not written consent was obtained; however, this practice was consistent with regulations at the time. The authors mistakenly cited approval by the Oxford Tropical Research Ethics Committee (OxTREC) for this study. Current regulations by Oxford University now stipulate that all human studies obtain institutional approval, and the regulations now require written consent (http://www.admin.ox.ac.uk/researchsupport/ctrg/furtherinfo/).

Version history
  • Version 1 (November 1, 2012): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts