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Usage Information

Telomeres and age-related disease: how telomere biology informs clinical paradigms
Mary Armanios
Mary Armanios
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):996-1002. https://doi.org/10.1172/JCI66370.
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Review Series

Telomeres and age-related disease: how telomere biology informs clinical paradigms

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Abstract

Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.

Authors

Mary Armanios

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 2,134 521
PDF 158 83
Figure 200 2
Citation downloads 114 0
Totals 2,606 606
Total Views 3,212
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