Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
Beate Lanske, … , Roland Baron, Henry M. Kronenberg
Beate Lanske, … , Roland Baron, Henry M. Kronenberg
Published August 15, 1999
Citation Information: J Clin Invest. 1999;104(4):399-407. https://doi.org/10.1172/JCI6629.
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Article

Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development

Abstract

Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP) bind to and activate the same PTH/PTHrP receptor. Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to acceleration of differentiation of growth plate chondrocytes. To explore further the functional relationships of PTHrP and the PTH/PTHrP receptor, bones of knockout mice were analyzed early in development, and the phenotypes of double-knockout mice were characterized.

Authors

Beate Lanske, Michael Amling, Lynn Neff, Jennifer Guiducci, Roland Baron, Henry M. Kronenberg

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Delay in replacement of cartilage by bone. Methylmethacrylate sections o...
Delay in replacement of cartilage by bone. Methylmethacrylate sections of phalanges at E18.5 (a–c) and paraffin sections of tibiae at E16.5 (d–f) of wild-type, PTH/PTHrP-R–/–, and PTHrP–/– animals. Blood vessel invasion and deposition of bone by osteoblasts are delayed in PTH/PTHrP-R–/– bones (b and e) when compared with wild-type bones (a and d). In contrast, in PTHrP–/– bones, these processes are advanced (c and f).