Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and is characterized by recurring structural genetic alterations. Previous studies of DNA methylation suggest epigenetic alterations may also be important, but an integrated genome-wide analysis of genetic and epigenetic alterations in ALL has not been performed. We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases using microarray analysis of DNA copy number alterations and gene expression, and genome-wide cytosine methylation profiling using the
Maria E. Figueroa, Shann-Ching Chen, Anna K. Andersson, Letha A. Phillips, Yushan Li, Jason Sotzen, Mondira Kundu, James R. Downing, Ari Melnick, Charles G. Mullighan
Representation of the BCR and TCR signaling pathways and their regulation through DNA methylation.