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Usage Information

Sox9 and programming of liver and pancreatic progenitors
Yoshiya Kawaguchi
Yoshiya Kawaguchi
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Review Series

Sox9 and programming of liver and pancreatic progenitors

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Abstract

Recent advances in developmental biology have greatly expanded our understanding of progenitor cell programming and the fundamental roles that Sox9 plays in liver and pancreas organogenesis. In the last 2 years, several studies have dissected the behavior of the Sox9+ duct cells in adult organs, but conflicting results have left unanswered the long-standing question of whether physiologically functioning progenitors exist in adult liver and pancreas. On the other hand, increasing evidence suggests that duct cells function as progenitors in the tissue restoration process after injury, during which embryonic programs are sometimes reactivated. This article discusses the role of Sox9 in programming liver and pancreatic progenitors as well as controversies in the field.

Authors

Yoshiya Kawaguchi

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 1,227 78
PDF 212 9
Figure 883 4
Citation downloads 193 0
Totals 2,515 91
Total Views 2,606
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ISSN: 0021-9738 (print), 1558-8238 (online)

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