After cell fate specification, differentiating cells must amplify the specific subcellular features required for their specialized function. How cells regulate such subcellular scaling is a fundamental unanswered question. Here, we show that the E3 ubiquitin ligase Mindbomb 1 (MIB1) is required for the apical secretory apparatus established by gastric zymogenic cells as they differentiate from their progenitors. When
Benjamin J. Capoccia, Ramon U. Jin, Young-Yun Kong, Richard M. Peek Jr., Matteo Fassan, Massimo Rugge, Jason C. Mills
Microtubules and MAP1B coordinate apical compartment expansion and endolysosomal trafficking in gastric ZCs.