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The role of aging upon β cell turnover
Jake A. Kushner
Jake A. Kushner
Published March 1, 2013
Citation Information: J Clin Invest. 2013;123(3):990-995. https://doi.org/10.1172/JCI64095.
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Review Series

The role of aging upon β cell turnover

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Abstract

Preservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena.

Authors

Jake A. Kushner

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Figure 1

Proposed model of β cell regeneration capacity.

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Proposed model of β cell regeneration capacity.
Basal β cell replication...
Basal β cell replication capacity continuously decreases from early adulthood to middle age. As basal β cell replication drops to very low levels, adaptive capacity is greatly decreased.

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