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Usage Information

Malonyl-CoA: the regulator of fatty acid synthesis and oxidation
Daniel W. Foster
Daniel W. Foster
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Hindsight

Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

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Abstract

In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our understanding of molecular metabolism.

Authors

Daniel W. Foster

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Usage data is cumulative from September 2025 through September 2026.

Usage JCI PMC
Text version 4,590 1,133
PDF 426 148
Figure 371 0
Citation downloads 254 0
Totals 5,641 1,281
Total Views 6,922
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ISSN: 0021-9738 (print), 1558-8238 (online)

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