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Usage Information

Molecular and genetic basis of sudden cardiac death
Alfred L. George Jr.
Alfred L. George Jr.
Published January 2, 2013
Citation Information: J Clin Invest. 2013;123(1):75-83. https://doi.org/10.1172/JCI62928.
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Review Series

Molecular and genetic basis of sudden cardiac death

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Abstract

The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause sudden and unexpected death at any age, a syndrome called sudden cardiac death (SCD). Annually, more than 300,000 cases of SCD occur in the United States alone, making this a major public health concern. Our current understanding of the mechanisms responsible for SCD has emerged from decades of basic science investigation into the normal electrophysiology of the heart, the molecular physiology of cardiac ion channels, fundamental cellular and tissue events associated with cardiac arrhythmias, and the molecular genetics of monogenic disorders of heart rhythm. This knowledge has helped shape the current diagnosis and treatment of inherited arrhythmia susceptibility syndromes associated with SCD and has provided a pathophysiological framework for understanding more complex conditions predisposing to this tragic event. This Review presents an overview of the molecular basis of SCD, with a focus on monogenic arrhythmia syndromes.

Authors

Alfred L. George Jr.

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,065 135
PDF 80 30
Figure 334 1
Table 47 0
Citation downloads 77 0
Totals 1,603 166
Total Views 1,769
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