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Abstract
Endothelial cells from human umbilical veins were first cultured nearly four decades ago, initiating explosive growth in research in vascular biology and leading to major insights into angiogenesis, vasculogenesis, and tumor biology. Recent studies now promise to open new horizons in regenerative medicine as well as organ engineering.
Authors
Ralph L. Nachman
Figure 1
The endothelial cell symphony.
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The endothelial cells conduct luminal constitutive, anticoagulant, and antiinflammatory functions as well as nonconstitutive, activated, thromboregulatory activities. Furthermore, these cells secrete angiocrines, which orchestrate a number of different pathways, including embryonic organogenesis, hematopoiesis, metastasis, and lung and liver regeneration.
Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)