F-5 is superior to FDA-approved becaplermin/PDGF-BB in acute wound healing.
Full-thickness skin wounds (1 cm × 1 cm) in athymic nude mice were treated
(only once on day 0) with either 200 μl of 5% CMC gel (placebo) or the same
volume of the gel containing an optimized concentration of a given peptide:
(A) full-length, (B) F-2, (C) F-5, (D) F-6 (n = 3 mice per peptide, per
experiment), or (E) becaplermin (20 μg of PDGF-BB or 8 μM). Plus signs
indicate treated mice, and minus signs indicate placebo mice. The images of
1 representative experiment are shown.