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Usage Information

Slowing down with age: lung DCs do it too
Thomas J. Braciale, Taeg S. Kim
Thomas J. Braciale, Taeg S. Kim
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Slowing down with age: lung DCs do it too

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Abstract

Decline in immune function with age has been attributed to defects or alterations in both the innate and the adaptive immune system. In this issue of the JCI, Zhao and coworkers provide evidence for a novel mechanism of immune dysfunction in aging mice. They show that migration of respiratory DCs from the site of virus replication to the draining lymph nodes in response to infection with several different respiratory viruses is markedly diminished with increasing age. The impaired DC migration was a result of increased levels of the lipid mediator prostaglandin D2 (PGD2) in the respiratory tract with age and could be partially reversed by blockade of PGD2 synthesis or action.

Authors

Thomas J. Braciale, Taeg S. Kim

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 517 9
PDF 202 4
Figure 276 8
Citation downloads 181 0
Totals 1,176 21
Total Views 1,197

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ISSN: 0021-9738 (print), 1558-8238 (online)

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