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Usage Information

Molecular pathogenesis of mantle cell lymphoma
Pedro Jares, … , Dolors Colomer, Elias Campo
Pedro Jares, … , Dolors Colomer, Elias Campo
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3416-3423. https://doi.org/10.1172/JCI61272.
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Review Series

Molecular pathogenesis of mantle cell lymphoma

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Abstract

Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1 and the cell cycle, disruption of DNA damage response pathways, and activation of cell survival mechanisms contribute to oncogenesis. A small number of tumors lack cyclin D1 overexpression, suggesting that its dysregulation is always not required for tumor initiation. Some cases have hypermutated IGHV and stable karyotypes, a predominant nonnodal disease, and an indolent clinical evolution, which suggests that they may correspond to distinct subtypes of the disease. In this review, we discuss the molecular pathways that contribute to pathogenesis, and how improved understanding of these molecular mechanisms offers new perspectives for the treatment of patients.

Authors

Pedro Jares, Dolors Colomer, Elias Campo

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,610 327
PDF 187 179
Figure 639 14
Citation downloads 87 0
Totals 2,523 520
Total Views 3,043
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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