New molecular insights into peripheral T cell lymphomas
Stefano A. Pileri, Pier Paolo Piccaluga
Stefano A. Pileri, Pier Paolo Piccaluga
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New molecular insights into peripheral T cell lymphomas

Abstract

Peripheral T cell lymphomas (PTCLs) are heterogeneous neoplasms and represent about 12% of all lymphoid malignancies. They are often regarded as “orphan diseases,” a designation that does not reflect their real incidence but rather signifies the difficulties encountered in their classification, diagnosis, and treatment. Here we revise the current understanding of the pathobiological characteristics of the most common nodal PTCLs by focusing on the contribution given by high-throughput technologies and the identification of potential therapeutic targets proposed by translational studies.

Authors

Stefano A. Pileri, Pier Paolo Piccaluga

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Figure 1

Prevalence of genomic imbalances in terms of copy number variants in PTCL-NOS, based on SNP array karyotyping.

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Prevalence of genomic imbalances in terms of copy number variants in PTC...
Created with data from ref. 7.