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Usage Information

Molecular genetics of B-precursor acute lymphoblastic leukemia
Charles G. Mullighan
Charles G. Mullighan
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3407-3415. https://doi.org/10.1172/JCI61203.
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Review Series

Molecular genetics of B-precursor acute lymphoblastic leukemia

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Abstract

B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading cause of cancer-related death in children and young adults. The majority of B-ALL cases are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of disease. Recent studies have used microarrays and sequencing to comprehensively identify all somatic genetic alterations in acute lymphoblastic leukemia (ALL). These studies have identified cryptic or submicroscopic genetic alterations that define new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis. This article reviews these advances, discusses results from ongoing second-generation sequencing studies of ALL, and highlights challenges and opportunities for future genetic profiling approaches.

Authors

Charles G. Mullighan

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 2,079 1,139
PDF 180 128
Figure 346 1
Table 169 0
Citation downloads 95 0
Totals 2,869 1,268
Total Views 4,137
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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