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Usage Information

Intestinal carcinogenesis: IKK can go all the way
Yoshiaki Sunami, Thomas Wirth
Yoshiaki Sunami, Thomas Wirth
Published June 23, 2011
Citation Information: J Clin Invest. 2011;121(7):2551-2553. https://doi.org/10.1172/JCI58454.
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Commentary

Intestinal carcinogenesis: IKK can go all the way

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Abstract

Chronic inflammation has long been suspected to support tumorigenesis in a variety of cancers. The IκB kinase (IKK)/NF-κB pathway is the critical signal transduction pathway regulating inflammation, and loss-of-function studies have demonstrated its involvement in tumorigenesis. In this issue of the JCI, Vlantis et al. present evidence that persistent genetic activation of IKK/NF-κB signaling in intestinal epithelial cells not only accelerates tumorigenesis in models of both carcinogen- and mutation-induced colorectal cancer, but also is sufficient to induce intestinal tumors.

Authors

Yoshiaki Sunami, Thomas Wirth

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