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Usage Information

The yin, the yang, and the Angiopoietin-1
Pipsa Saharinen, Kari Alitalo
Pipsa Saharinen, Kari Alitalo
Published May 23, 2011
Citation Information: J Clin Invest. 2011;121(6):2157-2159. https://doi.org/10.1172/JCI58196.
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Commentary

The yin, the yang, and the Angiopoietin-1

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Abstract

Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice conditionally deleted of the Angpt1 gene. The results suggest that Angpt1 is needed as a vascular stabilizing factor that organizes and limits the angiogenesis response and protects from pathological consequences, such as tissue fibrosis.

Authors

Pipsa Saharinen, Kari Alitalo

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 656 131
PDF 87 29
Figure 137 0
Citation downloads 88 0
Totals 968 160
Total Views 1,128
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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