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The yin, the yang, and the Angiopoietin-1
Pipsa Saharinen, Kari Alitalo
Pipsa Saharinen, Kari Alitalo
Published May 23, 2011
Citation Information: J Clin Invest. 2011;121(6):2157-2159. https://doi.org/10.1172/JCI58196.
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Commentary

The yin, the yang, and the Angiopoietin-1

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Abstract

Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice conditionally deleted of the Angpt1 gene. The results suggest that Angpt1 is needed as a vascular stabilizing factor that organizes and limits the angiogenesis response and protects from pathological consequences, such as tissue fibrosis.

Authors

Pipsa Saharinen, Kari Alitalo

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