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Usage Information

Fibulin-5: two for the price of one maintaining pelvic support
Gina M. Northington
Gina M. Northington
Published April 25, 2011
Citation Information: J Clin Invest. 2011;121(5):1688-1691. https://doi.org/10.1172/JCI57438.
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Commentary

Fibulin-5: two for the price of one maintaining pelvic support

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Abstract

Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms, and available therapies are limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a new mechanism critical to the maintenance of pelvic organ support.

Authors

Gina M. Northington

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Figure 148 0
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