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Targeted therapies for breast cancer
Michaela J. Higgins, José Baselga
Michaela J. Higgins, José Baselga
Published October 3, 2011
Citation Information: J Clin Invest. 2011;121(10):3797-3803. https://doi.org/10.1172/JCI57152.
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Review Series

Targeted therapies for breast cancer

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Abstract

In recent years the description of well-defined molecular subtypes of breast cancer, together with the identification of the driving genetic alterations and signaling pathways, has led to the clinical development of a number of successful molecular targeted agents. This is best exemplified in the subset of HER2-amplified breast cancers, in which an increasing number of active agents are changing the natural history of this aggressive disease. Other targets are under exploration, and the clinical development of these agents will require a change from the current large, randomized trials in unselected patient populations to smaller trials in groups with a molecularly defined tumor type. In addition, combinatorial approaches that act on the secondary mutations and/or compensatory pathways in resistant tumors may markedly improve on the effects of targeted agents used alone.

Authors

Michaela J. Higgins, José Baselga

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Figure 1

Venn diagram of breast cancer subtypes and their overlapping molecular targets.

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Venn diagram of breast cancer subtypes and their overlapping molecular t...
Selected targeted treatment strategies are also depicted.

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