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Usage Information

HSV-2: in pursuit of a vaccine
Christine Johnston, … , David M. Koelle, Anna Wald
Christine Johnston, … , David M. Koelle, Anna Wald
Published December 1, 2011
Citation Information: J Clin Invest. 2011;121(12):4600-4609. https://doi.org/10.1172/JCI57148.
View: Text | PDF
Review Series

HSV-2: in pursuit of a vaccine

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Abstract

Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, we review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.

Authors

Christine Johnston, David M. Koelle, Anna Wald

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 2,271 217
PDF 98 33
Figure 51 2
Table 89 0
Supplemental data 43 0
Citation downloads 69 0
Totals 2,621 252
Total Views 2,873
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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