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HSV-2: in pursuit of a vaccine
Christine Johnston, … , David M. Koelle, Anna Wald
Christine Johnston, … , David M. Koelle, Anna Wald
Published December 1, 2011
Citation Information: J Clin Invest. 2011;121(12):4600-4609. https://doi.org/10.1172/JCI57148.
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Review Series

HSV-2: in pursuit of a vaccine

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Abstract

Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, we review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.

Authors

Christine Johnston, David M. Koelle, Anna Wald

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Figure 1

HSV-2 vaccine development strategies.

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HSV-2 vaccine development strategies.
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