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Breast cancer — one term, many entities?
Nicholas R. Bertos, Morag Park
Nicholas R. Bertos, Morag Park
Published October 3, 2011
Citation Information: J Clin Invest. 2011;121(10):3789-3796. https://doi.org/10.1172/JCI57100.
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Review Series

Breast cancer — one term, many entities?

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Abstract

Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors with different clinical characteristics, disease courses, and responses to specific treatments. Tumor-intrinsic features, including classical histological and immunopathological classifications as well as more recently described molecular subtypes, separate breast tumors into multiple groups. Tumor-extrinsic features, including microenvironmental configuration, also have prognostic significance and further expand the list of tumor-defining variables. A better understanding of the features underlying heterogeneity, as well as of the mechanisms and consequences of their interactions, is essential to improve targeting of existing therapies and to develop novel agents addressing specific combinations of features.

Authors

Nicholas R. Bertos, Morag Park

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Figure 1

Schematic depiction of normal breast architecture and breast tumor and surrounding stroma, illustrating some of the tumor-intrinsic and microenvironmental variables contributing to disease heterogeneity.

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Schematic depiction of normal breast architecture and breast tumor and s...
(A) Normal breast architecture. (B) Breast tumor and surrounding stroma. TAM, tumor-associated macrophage.
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