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Usage Information

Good COP1 or bad COP1? In vivo veritas
Wenyi Wei, William G. Kaelin Jr.
Wenyi Wei, William G. Kaelin Jr.
Published March 14, 2011
Citation Information: J Clin Invest. 2011;121(4):1263-1265. https://doi.org/10.1172/JCI57080.
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Commentary

Good COP1 or bad COP1? In vivo veritas

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Abstract

The evolutionarily conserved protein COP1 has been shown to operate as an E3 ubiquitin ligase complex, and a number of putative substrates have been identified, including the c-JUN oncoprotein and p53 tumor suppressor protein. New work by Migliorini and colleagues described in the current issue of JCI demonstrates that COP1 acts as a tumor suppressor in vivo and does so, at least in part, by promoting the destruction of c-JUN. These findings challenge the view that COP1 regulates p53 stability and call into question the wisdom of developing COP1 inhibitors as potential anticancer agents.

Authors

Wenyi Wei, William G. Kaelin Jr.

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 374 22
PDF 74 13
Figure 129 0
Citation downloads 64 0
Totals 641 35
Total Views 676
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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