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Usage Information

Nuclear receptors take center stage in Th17 cell–mediated autoimmunity
Jennifer J. Heller, Ju Qiu, Liang Zhou
Jennifer J. Heller, Ju Qiu, Liang Zhou
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Nuclear receptors take center stage in Th17 cell–mediated autoimmunity

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Abstract

Liver X receptors (LXRs) are nuclear receptors involved in cholesterol homeostasis. Notably, they are also expressed by T cells and are involved in regulating T cell proliferation and differentiation. In this issue of the JCI, Cui et al. have elucidated the molecular mechanism underlying the effects of LXR activation on a subset of T cells known as Th17 cells in mice and humans. Specifically, they showed that LXR-induced Srebp-1 inhibits Il17 transcription by binding to the Il17 promoter through interaction with the aryl hydrocarbon receptor (Ahr), a transcription factor known to enhance Th17 cell responses.

Authors

Jennifer J. Heller, Ju Qiu, Liang Zhou

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 495 26
PDF 175 7
Figure 115 2
Citation downloads 151 0
Totals 936 35
Total Views 971
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