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Usage Information

Sixteen years and counting: an update on leptin in energy balance
Laurent Gautron, Joel K. Elmquist
Laurent Gautron, Joel K. Elmquist
Published June 1, 2011
Citation Information: J Clin Invest. 2011;121(6):2087-2093. https://doi.org/10.1172/JCI45888.
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Review Series

Sixteen years and counting: an update on leptin in energy balance

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Abstract

Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles.

Authors

Laurent Gautron, Joel K. Elmquist

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 1,481 93
PDF 95 32
Figure 84 1
Table 70 0
Citation downloads 786 0
Totals 2,516 126
Total Views 2,642
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