Acute kidney injury predisposes patients to the development of both chronic kidney disease and end-stage renal failure, but the molecular details underlying this important clinical association remain obscure. We report that kidney injury molecule-1 (KIM-1), an epithelial phosphatidylserine receptor expressed transiently after acute injury and chronically in fibrotic renal disease, promotes kidney fibrosis. Conditional expression of KIM-1 in renal epithelial cells (
Benjamin D. Humphreys, Fengfeng Xu, Venkata Sabbisetti, Ivica Grgic, Said Movahedi Naini, Ningning Wang, Guochun Chen, Sheng Xiao, Dhruti Patel, Joel M. Henderson, Takaharu Ichimura, Shan Mou, Savuth Soeung, Andrew P. McMahon, Vijay K. Kuchroo, Joseph V. Bonventre
KIM-1 is highly induced in fibrotic kidney injury adjacent to interstitial myofibroblasts.