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Usage Information

Virulence determinants of pandemic influenza viruses
Donna M. Tscherne, Adolfo García-Sastre
Donna M. Tscherne, Adolfo García-Sastre
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Science in Medicine

Virulence determinants of pandemic influenza viruses

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Abstract

Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality. The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential. Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak. Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics.

Authors

Donna M. Tscherne, Adolfo García-Sastre

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 4,842 187
PDF 219 27
Figure 399 0
Table 99 0
Citation downloads 169 0
Totals 5,728 214
Total Views 5,942
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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