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Usage Information

Comeback kids: CD8+ suppressor T cells are back in the game
Luc Van Kaer
Luc Van Kaer
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Commentary

Comeback kids: CD8+ suppressor T cells are back in the game

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Abstract

Suppressing unwanted immune responses without compromising host immunity against pathogens is considered the holy grail of immunology. Lack of responsiveness to self-antigens is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this issue of the JCI, Jiang and colleagues define a CD8+ suppressor T cell subset in humans that recapitulates a regulatory pathway previously described in mice. These investigators further show that patients with type 1 diabetes have defects in their CD8+ suppressor T cells, thus identifying these cells as potential therapeutic targets in human disease.

Authors

Luc Van Kaer

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Usage data is cumulative from September 2025 through September 2026.

Usage JCI PMC
Text version 1,132 23
PDF 250 6
Figure 183 0
Citation downloads 177 0
Totals 1,742 29
Total Views 1,771
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ISSN: 0021-9738 (print), 1558-8238 (online)

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