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Usage Information

Pain imaging in health and disease — how far have we come?
Petra Schweinhardt, M. Catherine Bushnell
Petra Schweinhardt, M. Catherine Bushnell
Published November 1, 2010
Citation Information: J Clin Invest. 2010;120(11):3788-3797. https://doi.org/10.1172/JCI43498.
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Review Series

Pain imaging in health and disease — how far have we come?

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Abstract

Since modern brain imaging of pain began 20 years ago, networks in the brain related to pain processing and those related to different types of pain modulation, including placebo, have been identified. Functional and anatomical connectivity of these circuits has begun to be analyzed. Imaging in patients suggests that chronic pain is associated with altered function and structural abnormalities in pain modulatory circuits. Moreover, biochemical alterations associated with chronic pain are being identified that provide information on cellular correlates as well as potential mechanisms of structural changes. Data from these brain imaging studies reinforce the idea that chronic pain leads to brain changes that could have functional significance.

Authors

Petra Schweinhardt, M. Catherine Bushnell

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,494 195
PDF 134 90
Figure 341 3
Citation downloads 90 0
Totals 2,059 288
Total Views 2,347
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