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Usage Information

Nociceptors: the sensors of the pain pathway
Adrienne E. Dubin, Ardem Patapoutian
Adrienne E. Dubin, Ardem Patapoutian
Published November 1, 2010
Citation Information: J Clin Invest. 2010;120(11):3760-3772. https://doi.org/10.1172/JCI42843.
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Review Series

Nociceptors: the sensors of the pain pathway

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Abstract

Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of information they convey provide a rich diversity of pain qualities. Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.

Authors

Adrienne E. Dubin, Ardem Patapoutian

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 10,176 14,877
PDF 1,132 1,300
Figure 704 14
Table 404 0
Citation downloads 246 0
Totals 12,662 16,191
Total Views 28,853
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