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Usage Information

Uric acid transport and disease
Alexander So, Bernard Thorens
Alexander So, Bernard Thorens
Published June 1, 2010
Citation Information: J Clin Invest. 2010;120(6):1791-1799. https://doi.org/10.1172/JCI42344.
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Science in Medicine

Uric acid transport and disease

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Abstract

Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.

Authors

Alexander So, Bernard Thorens

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 3,829 1,470
PDF 326 236
Figure 1,313 16
Citation downloads 127 0
Totals 5,595 1,722
Total Views 7,317
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