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Resolution of immune activation defines nonpathogenic SIV infection
Olivier Manches, Nina Bhardwaj
Olivier Manches, Nina Bhardwaj
Published November 23, 2009
Citation Information: J Clin Invest. 2009;119(12):3512-3515. https://doi.org/10.1172/JCI41509.
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Commentary

Resolution of immune activation defines nonpathogenic SIV infection

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Abstract

Natural nonhuman primate hosts of SIV do not succumb to AIDS despite significant viral replication, a phenomenon attributed to reduced levels of chronic and deleterious “immune activation.” Two studies in this issue of the JCI, by Bosinger et al. and Jacquelin et al., now show that SIV induces vigorous immune activation and upregulation of IFN-stimulated genes in both natural and susceptible hosts, but strikingly, the responses resolve only in the former (see the related articles, beginning on pages 3556 and 3544, respectively). Thus, natural hosts for SIV actively engage mechanisms to abort sustained immune activation and its associated harmful effects.

Authors

Olivier Manches, Nina Bhardwaj

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