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Usage Information

Portrait of an oocyte: our obscure origin
Roger Gosden, Bora Lee
Roger Gosden, Bora Lee
Published April 1, 2010
Citation Information: J Clin Invest. 2010;120(4):973-983. https://doi.org/10.1172/JCI41294.
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Review Series

Portrait of an oocyte: our obscure origin

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Abstract

Oocytes play a pivotal role in the cycle of human life. As we discuss here, after emerging from germline stem cells in the fetus, they grow in a follicular niche in which development is harmonized for timely ovulation and hormone secretion after puberty. Most human oocytes have poor developmental competence and are peculiarly vulnerable to chromosomal malsegregation, especially as women pass the optimal years of fertility and may begin to turn to assisted reproductive technologies (ARTs) and egg donation. Research needs to focus on the molecular factors involved and the environmental niche required for optimal development of oocytes, with the aim of increasing their numbers and quality for ARTs, since these are the factors that so often limit human fertility.

Authors

Roger Gosden, Bora Lee

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Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
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PDF 120 47
Figure 1,176 7
Table 51 0
Citation downloads 88 0
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Total Views 4,151
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