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Stem cells in human neurodegenerative disorders — time for clinical translation?
Olle Lindvall, Zaal Kokaia
Olle Lindvall, Zaal Kokaia
Published January 4, 2010
Citation Information: J Clin Invest. 2010;120(1):29-40. https://doi.org/10.1172/JCI40543.
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Review Series

Stem cells in human neurodegenerative disorders — time for clinical translation?

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Abstract

Stem cell–based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and glial cells and by mediating remyelination, trophic actions, and modulation of inflammation. Endogenous neural stem cells are also potential therapeutic targets because they produce neurons and glial cells in response to injury and could be affected by the degenerative process. As we discuss here, however, significant hurdles remain before these findings can be responsibly translated to novel therapies. In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment.

Authors

Olle Lindvall, Zaal Kokaia

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Figure 2

Stem cell–based therapies for ALS.

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Stem cell–based therapies for ALS.
ALS leads to degeneration of motor ne...
ALS leads to degeneration of motor neurons in the cerebral cortex, brainstem, and spinal cord. Stem cell–based therapy could be used to induce neuroprotection or dampen detrimental inflammation by implanting stem cells releasing growth factors. Alternatively, stem cell–derived spinal motor neuron precursors/neuroblasts could be transplanted into damaged areas to replace damaged or dead neurons.

Copyright © 2021 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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