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Stem cells in human neurodegenerative disorders — time for clinical translation?
Olle Lindvall, Zaal Kokaia
Olle Lindvall, Zaal Kokaia
Published January 4, 2010
Citation Information: J Clin Invest. 2010;120(1):29-40. https://doi.org/10.1172/JCI40543.
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Review Series

Stem cells in human neurodegenerative disorders — time for clinical translation?

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Abstract

Stem cell–based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and glial cells and by mediating remyelination, trophic actions, and modulation of inflammation. Endogenous neural stem cells are also potential therapeutic targets because they produce neurons and glial cells in response to injury and could be affected by the degenerative process. As we discuss here, however, significant hurdles remain before these findings can be responsibly translated to novel therapies. In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment.

Authors

Olle Lindvall, Zaal Kokaia

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Figure 1

Stem cell–based therapies for PD.

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Stem cell–based therapies for PD.
PD leads to the progressive death of D...
PD leads to the progressive death of DA neurons in the substantia nigra and decreased DA innervation of the striatum, primarily the putamen. Stem cell–based approaches could be used to provide therapeutic benefits in two ways: first, by implanting stem cells modified to release growth factors, which would protect existing neurons and/or neurons derived from other stem cell treatments; and second, by transplanting stem cell–derived DA neuron precursors/neuroblasts into the putamen, where they would generate new neurons to ameliorate disease-induced motor impairments.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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