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Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
Francesco Saverio Tedesco, … , Graziella Messina, Giulio Cossu
Francesco Saverio Tedesco, … , Graziella Messina, Giulio Cossu
Published January 4, 2010
Citation Information: J Clin Invest. 2010;120(1):11-19. https://doi.org/10.1172/JCI40373.
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Review Series

Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells

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Abstract

Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.

Authors

Francesco Saverio Tedesco, Arianna Dellavalle, Jordi Diaz-Manera, Graziella Messina, Giulio Cossu

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Figure 2

Derivation of different stem cells for possible use in skeletal muscle regeneration.

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Derivation of different stem cells for possible use in skeletal muscle r...
The figure shows a flow chart with the sources of different myogenic stem cells. The possibility of deriving the same cells from a reprogrammed cell of the dermis is also outlined (blue boxes and arrows). Once obtained, the stem cells can be characterized, expanded, genetically corrected, and transplanted.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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