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Usage Information

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
Barbara Rehermann
Barbara Rehermann
Published July 1, 2009
Citation Information: J Clin Invest. 2009;119(7):1745-1754. https://doi.org/10.1172/JCI39133.
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Science in Medicine

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

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Abstract

Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been made in our understanding of its life cycle and interaction with the host immune system. Much has been learned from HCV itself, which, via decades of coevolution, gained an intricate knowledge of host innate and adaptive immune responses and developed sophisticated ways to preempt, subvert, and antagonize them. This review discusses the clinical, virological, and immunological features of acute and chronic hepatitis C and the role of the immune response in spontaneous and treatment-induced HCV clearance.

Authors

Barbara Rehermann

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,130 65
PDF 73 27
Figure 180 3
Supplemental data 45 0
Citation downloads 59 0
Totals 1,487 95
Total Views 1,582
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