Abstract
Bipolar disorder (BPD) is a devastating illness that is characterized by recurrent
episodes of mania and depression. In addition to these cyclic episodes, individuals
with BPD exhibit changes in psychovegetative function, cognitive performance, and
general health and well being. In this article we draw from neuroimaging findings in
humans, postmortem data, and human genetic and pharmacological studies as well as
data from animal models of behavior to discuss the neurobiology of BPD. We conclude
with a synthesis of where the field stands and with suggestions and strategies for
future areas of study to further increase our conceptual understanding of this
complex illness.
Authors
Keri Martinowich, Robert J. Schloesser, Husseini K. Manji
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