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Usage Information

Evidence that cytokines play a role in rheumatoid arthritis
Fionula M. Brennan, Iain B. McInnes
Fionula M. Brennan, Iain B. McInnes
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Review Series

Evidence that cytokines play a role in rheumatoid arthritis

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Abstract

A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA). It is now clear that these cytokines play a fundamental role in the processes that cause inflammation, articular destruction, and the comorbidities associated with RA. Following the success of TNF-α blockade as a treatment for RA, other cytokines now offer alternative targets for therapeutic intervention or might be useful as predictive biomarkers of disease. In this Review, we discuss the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-α, IL-1, IL-6, IL-23, and IL-2 families.

Authors

Fionula M. Brennan, Iain B. McInnes

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Usage data is cumulative from May 2025 through May 2026.

Usage JCI PMC
Text version 3,491 259
PDF 264 60
Figure 471 10
Table 98 0
Citation downloads 211 0
Totals 4,535 329
Total Views 4,864
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