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Usage Information

Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family
H. Michael Shepard, … , Cathleen M. Brdlik, Hans Schreiber
H. Michael Shepard, … , Cathleen M. Brdlik, Hans Schreiber
Published November 3, 2008
Citation Information: J Clin Invest. 2008;118(11):3574-3581. https://doi.org/10.1172/JCI36049.
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Review Series

Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family

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Abstract

The human EGFR (HER) family is essential for communication between many epithelial cancer cell types and the tumor microenvironment. Therapeutics targeting the HER family have demonstrated clinical success in the treatment of diverse epithelial cancers. Here we propose that the success of HER family–targeted monoclonal antibodies in cancer results from their ability to interfere with HER family consolidation of signals initiated by a multitude of other receptor systems. Ligand/receptor systems that initiate these signals include cytokine receptors, chemokine receptors, TLRs, GPCRs, and integrins. We further extrapolate that improvements in cancer therapeutics targeting the HER family are likely to incorporate mechanisms that block or reverse stromal support of malignant progression by isolating the HER family from autocrine and stromal influences.

Authors

H. Michael Shepard, Cathleen M. Brdlik, Hans Schreiber

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,046 30
PDF 76 12
Figure 139 1
Table 41 0
Citation downloads 74 0
Totals 1,376 43
Total Views 1,419
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