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Usage Information

Chemical modification: the key to clinical application of RNA interference?
David R. Corey
David R. Corey
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Review Series

Chemical modification: the key to clinical application of RNA interference?

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Abstract

RNA interference provides a potent and specific method for controlling gene expression in human cells. To translate this potential into a broad new family of therapeutics, it is necessary to optimize the efficacy of the RNA-based drugs. As discussed in this Review, it might be possible to achieve this optimization using chemical modifications that improve their in vivo stability, cellular delivery, biodistribution, pharmacokinetics, potency, and specificity.

Authors

David R. Corey

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Usage data is cumulative from December 2024 through December 2025.

Usage JCI PMC
Text version 1,187 123
PDF 110 18
Figure 134 0
Table 98 0
Citation downloads 113 0
Totals 1,642 141
Total Views 1,783
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