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Taking aim at translation for tumor therapy
Bryan C. Barnhart, M. Celeste Simon
Bryan C. Barnhart, M. Celeste Simon
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2385-2388. https://doi.org/10.1172/JCI33107.
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Commentary

Taking aim at translation for tumor therapy

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Abstract

Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting genes. In this issue of the JCI, Graff and colleagues describe potent antitumor effects using second-generation antisense oligonucleotides for eIF4E (see the related article beginning on page 2638). If their results are recapitulated in a clinical setting, this strategy will provide a promising antitumor therapy with broad-reaching applications.

Authors

Bryan C. Barnhart, M. Celeste Simon

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