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Usage Information

The legacy of the Philadelphia chromosome
Gary A. Koretzky
Gary A. Koretzky
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Review Series Introduction

The legacy of the Philadelphia chromosome

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Abstract

The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered. This Review series includes contributions from individuals who performed critical experiments addressing some of the most important of these questions, reflecting the nearly 50 years of work inspired by Nowell’s initial finding. The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease.

Authors

Gary A. Koretzky

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Usage data is cumulative from March 2025 through March 2026.

Usage JCI PMC
Text version 1,225 1,406
PDF 278 86
Figure 235 2
Citation downloads 223 0
Totals 1,961 1,494
Total Views 3,455
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ISSN: 0021-9738 (print), 1558-8238 (online)

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